Balakrishnan A, Chang AN, Huskey N, Bhat B, Jones KD, Lee J, Marcusson EG, Goga A. microRNA-21 Inhibition leads to Prolonged Survival of Mice with Hepatocellular Carcinoma. J Exp Med, submitted.
Hogan DJ, Vincent TM, Fish S, Marcusson EG, Bhat B, Chau BN, Zisoulis DG. Anti-miRs competitively inhibit microRNAs in Argonaute complexes. PLoS One. 2014 Jul 3;9(7):e100951.
Zhou W, Fong MY, Yu Y, Chow C, Somlo G, Palomares MR, O’Connor STF, Chin AR, Marcusson EG, Chu P, Wu X, Li AX, Li Z, Ren X, Boldin M, Wang SE. Cancer-derived miR-105 promotes tumor invasion and destroys the natural barriers against metastasis. Cancer Cell, 2014 Apr 14;25(4):501-15.
Jin L, Wessely O, Marcusson EG, Ivan C, Calin G, Alahari S. Pro-oncogenic factors miR-23b- and miR-27b are regulated by Her2/Neu, EGF, and TNFα in breast cancer. Cancer Res. 2013 May 1;73(9):2884-96.
Lin R, Roychowdhury-Saha M, Black C, Watt AT, Marcusson EG, Freier SM, Edgington TS. Control of RNA processing by a large non-coding RNA over-expressed in carcinomas. FEBS Lett. 2011 Feb 18;585(4):671-6.
Carrasco RA, Stamm NB, Marcusson E, Sandusky G, Iversen P, Patel BK. Antisense inhibition of survivin expression as a cancer therapeutic. Mol Cancer Ther. 2011 Feb;10(2):221-32.
Huynh C, Segura MF, Gaziel-Sovran A, Menendez S, Darvishian F, Chiriboga L, Levin B, Meruelo D, Osman I, Zavadil J, Marcusson EG, Hernando E. Efficient in vivo microRNA targeting of liver metastasis. Oncogene. 2011 Mar 24;30(12):1481-8.
Elyakim E, Sitbon E, Faerman A, Tabak S, Montia E, Belanis L, Dov A, Marcusson EG, Bennett CF, Chajut A, Cohen D, Yerushalmi N. hsa-miR-191 is a candidate oncogene target for hepatocellular carcinoma therapy. Cancer Res. 2010 Oct 15;70(20):8077-87.
Swarbrick A, Woods SL, Shaw A, Balakrishnan A, Phua Y, Nguyen A, Chanthery Y, Lim L, Ashton LJ, Judson RL, Huskey N, Blelloch R, Haber M, Norris MD, Lengyel P, Hackett CS, Preiss T, Chetcuti A, Sullivan CS, Marcusson EG, Weiss W, L’Etoile N, Goga A. miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma. Nat Med. 2010 Oct;16(10):1134-40.
Nannuru KC, Futakuchi M, Varney ML, Vincent TM, Marcusson EG, Singh RK. Matrix metalloproteinase (MMP)-13 regulates mammary tumor-induced osteolysis by activating MMP9 and transforming growth factor-beta signaling at the tumor-bone interface. Cancer Res. 2010 May 1;70(9):3494-504.
Ma L, Reinhardt F, Pan E, Soutschek J, Bhat B, Marcusson EG, Teruya-Feldstein J, Bell GW, Weinberg RA. Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model. Nat Biotechnol. 2010 Apr;28(4):341-7.
Nannuru KC, Futakuchi M, Sadanandam A, Wilson TJ, Varney ML, Myers KJ, Li X, Marcusson EG, Singh RK. Enhanced expression and shedding of receptor activator of NF-kappaB ligand during tumor-bone interaction potentiates mammary tumor-induced osteolysis. Clin Exp Metastasis. 2009;26(7):797-808.
Ernst M, Najdovska M, Grail D, Lundgren-May T, Buchert M, Tye H, Matthews VB, Armes J, Bhathal PS, Hughes NR, Marcusson EG, Karras JG, Na S, Sedgwick JD, Hertzog PJ, Jenkins BJ. STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice. J. of Clin. Invest. 2008 May 1;118(5):1727-1738.
GraffJR, KonicekBW, Carter JH, Marcusson EG. Targeting the eukaryotic translation initiation factor 4E (eIF4E) for cancer therapy. Cancer Res. 2008 Feb 1;68(3):631-4.
Graff JR, Konicek BW, Vincent TM, Lynch RL, Monteith D, Weir SN, Schwier P, Capen A, Goode RL, Dowless MS, Chen Y, Zhang H, Sissons S, Cox K, McNulty AM, Parsons SH, Wang T, Sams L, Geeganage S, Douglass LE, Neubauer BL, Dean NM, Blanchard K, Shou J, Stancato LF, Carter JH, Marcusson EG. Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity. J Clin Invest. 2007 Sep;117(9):2638-48.
Low J, Huang S, Dowless M, Blosser W, Higgs R, Vincent TM, Davis S, Hodgson J, Koller E, Marcusson EG, Blanchard K, Stancato L. Statistical analysis of knockdown effects of validated siRNAs and antisense oligonucleotides using high-content imaging. J. of Biomolecular Screening. 2007 Sep;12(6):775-88.
Kim Y, Yoon JW, Xiao X, Dean NM, Monia BP, Marcusson EG. Selective downregulation of glioma-associated oncogene 2 (Gli2) inhibits the proliferation of hepatocellular carcinoma cells. Cancer Res. 2007 Apr 15;67(8):3583-93.
Habens F, Lapham AS, Dallman CL, Pickering BM, Michels J, Marcusson EG, Johnson PW, Packham G. Distinct promoters mediate constitutive and inducible Bcl-X(L) expression in malignant lymphocytes. Oncogene. 2007 Mar 22;26(13):1910-9.
Koller E, Propp S, Murray H, Lima W, Bhat B, Prakash TP, Allerson CW, Swayze EE, Marcusson EG, Dean NM. Competition for RISC binding predicts in vitro potency of siRNA. Nucleic Acids Res. 2006;34(16):4467-76.
Perera RJ, Marcusson EG, Koo S, Kang X, Kim Y, White N, Dean NM. Identification of novel PPARg target genes in primary human adipocytes. Gene. 2006 Mar 15;369:90-9.
Esau E, Kang X, Peralta E, Hanson E, Marcusson EG, Ravichandran LV, Sun Y, Koo S, Perera RJ, Jain R, Dean NM, Freier SM, Bennett CF, Lollo B, Griffey R. MicroRNA-143 regulates adipocyte differenetiation. J Biol Chem. 2004;279: 52361-52365.
Henry SP, Marcusson EG, Vincent TM, Dean NM. Setting sights on the treatment of ocular angiogenesis using antisense oligonucleotides. Trends Pharmacol Sci. 2004 Oct; 25(10):523-27.
Marcusson EG, Vincent TM, Hari KL, Chiang MY, Dean NM. Case study: use of a library of antisense inhibitors for gene functionalization and drug target validation. Drug Discovery Today: TARGETS. 2004 Jun; 3(3): 117-22.
Michels J, O’Neill JW, Dallman CL, Mouzakiti A, Habens F, Brimmell M, Zhang KY, Craig RW, Marcusson EG, Johnson PW, Packham G. Mcl-1 is required for Akata6 B-lymphoma cell survival and is converted to a cell death molecule by efficient caspase-mediated cleavage. Oncogene. 2004 Jun 17;23(28):4818-27.
Ravichandran LV, Dean NM, Marcusson EG. Use of antisense oligonucleotides in functional genomics and target validation. Oligonucleotides. 2004 Spring;14(1): 49-64.
Beger C, Pierce LN, Kruger M, Marcusson EG, Robbins JM, Welcsh P, Welch PJ, Welte K, King MC, Barber JR, Wong-Staal F. Identification of Id4 as a regulator of BRCA1 expression by using a ribozyme-library-based inverse genomics approach. Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):130-5.
Welch, P. J., Marcusson, E. G., Li, Q. X., Zhou, C., Beger, C., Krueger, M., Barber, J. Identification and validation of a potential human tumor suppressor gene using a library of randomized hairpin ribozymes. Genomics. 2000 Jun 15;66(3):274-83.
Taylor, J. K., Zhang, Q. Q., Monia, B. P., Marcusson, E. G., and Dean, N. M. Inhibiton of Bcl-XL expression sensitizes normal human keratinocytes and epithelial cells to apoptotic stimuli. Oncogene. 1999 Aug 5;18(31):4495-504.
Marcusson, E. G., Yacyshyn B. R, Shanahan, W., and Dean, N. M. Preclinical and clinical pharmacology of antisense oligonucleotides. Mol Biotechnol. 1999 Aug;12(1):1-11.
Marcusson, E. G., Bhat, B., Manoharan, M., Bennett, C. F., and Dean, N. M. Phosphorothioate oligodeoxynucleotides dissociate from cationic lipids before entering the nucleus. Nucleic Acids Res. 1998; 26, 2016-2023.
Seaman, M. N., Marcusson, E. G., Cereghino, J. L., and Emr, S. D. Endosome to Golgi retrieval of the vacuolar protein sorting receptor, Vps10p, requires the function of the VPS29, VPS30, and VPS35 gene products. J Cell Biol. 1997; 137, 79-92.
Westphal, V., Marcusson, E. G., Winther, J. R., Emr, S. D., and van den Hazel, H. B. Multiple pathways for vacuolar sorting of yeast proteinase A. J Biol Chem. 1996; 271, 11865-70.
Cereghino, J. L., Marcusson, E. G., and Emr, S. D. The cytoplasmic tail domain of the vacuolar protein sorting receptor Vps10p and a subset of VPS gene products regulate receptor stability, function, and localization. Mol Biol Cell. 1995; 6, 1089-102.
Stack, J. H., Herman, P. K., DeWald, D. B., Marcusson, E. G., Lin Cereghino, J., Horazdovsky, B. F., and Emr, S. D. Novel protein kinase/phosphatidylinositol 3-kinase complex essential for receptor-mediated protein sorting to the vacuole in yeast. Cold Spring Harb Symp Quant Biol. 1995; 60, 157-70.
Marcusson, E. G., Horazdovsky, B. F., Cereghino, J. L., Gharakhanian, E., and Emr, S. D. The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene. Cell. 1994; 77, 579-86.
Schnaper, H. W., Cottel, J., Merrill, S., Marcusson, E., Kissane, J. M., Shackelford, G. D., So, S. K., Nelson, R. D., Cole, B. R., Smith, M. L., and et al. Early occurrence of end-stage renal disease in a patient with infantile nephropathic cystinosis. J Pediatr. 1992; 120, 575-8.
Greene, A. A., Marcusson, E. G., Morell, G. P., and Schneider, J. A. Characterization of the lysosomal cystine transport system in mouse L- 929 fibroblasts. J Biol Chem. 1990; 265, 9888-95.
Smith, M. L., Clark, K. F., Davis, S. E., Greene, A. A., Marcusson, E. G., Chen, Y. J., and Schneider, J. A. Diagnosis of cystinosis with use of placenta [letter]. N Engl J Med. 1989; 321, 397-8.